The Monastery of Mor Hananyo, popularly known as Dayr al-Za'faran, served as a premier bastion of Syriac scholarship. Records indicate that the monastery’s influence was vast, producing a staggering number of high-ranking clergy, including twenty one Patriarchs, nine Maphryonos, and one hundred and ten bishops. The monastery emerged as a major center of learning following its re-construction in the late eighth and ninth centuries on the site of an even older monastic foundation. Between 816 and 1177, Patriarch Michael Rabo noted the graduation of twenty-eight bishops, including such luminaries as Mor Youhana, the renowned theologian and Bishop of Dara, and Severus, Bishop of Samosata. The school’s influence persisted through the following centuries with notable figures such as Iwanis, the Bishop of Harran, and the thirteenth-century scholar Patriarch Ignatius ibn Wahib. Other significant graduates included Daniel al-Mardini, an influential figure in the fourteenth century, and Patriarch Yohanna ibn Shay' Allah al-Bartali, who led the church in the late fifteenth century.
The intellectual heart of the monastery was its library, established in the late eighth century by Mor Hananyo, the Metropolitan of Mardin. The collection was significantly expanded and reorganized in the twelfth century by Bishop John of Mardin. Once the monastery became the official Patriarchal See around 1293, the library’s importance surged, eventually housing a substantial collection of manuscripts dating back to the ninth century. These texts covered a diverse array of disciplines, ranging from theology, jurisprudence, and asceticism to grammar, philology, and the study of Syriac belles-lettres. The library also preserved vital historical records, such as the biographies of the Patriarchs authored by the monk Timothy ‘Isa.
Though the formal school eventually declined due to the tribulations that befell the region, a tradition of education persisted through more informal, traditional methods. A new era of modern education began in 1905 when Dionysius Behnam Samarchi opened a school that expanded the curriculum beyond religious sciences to include Syriac, Arabic, and Turkish languages, as well as mathematics and foreign sciences. This initiative was later advanced by Patriarch Ignatius Aphram Barsoum, who both studied and taught at the site. Throughout its history, the monastery was shaped by dedicated educators like 'Abd al-Nur Haddad, a master of the Syriac language, and distinguished graduates like John of Dara, who remains one of the most celebrated scholars to have emerged from this sacred institution.